How long does a sinus infection last? A sinus infection has similar symptoms to a common cold. The big difference between the two is how long those symptoms linger. Sinusitis symptoms typically last no longer than 10 days. Chronic sinusitis can last for 12 weeks or longer. Sinus infections almost always get better on their own. Antibiotics won’t help a sinus infection caused by a virus or an airborne irritation, like secondhand smoke. But there are some things you can do to try to speed ...